Intraperitoneally Injected Melanin is Highly Uveitogenic
نویسندگان
چکیده
منابع مشابه
Recoverin is highly uveitogenic in Lewis rats.
PURPOSE Recoverin, a calcium-binding protein that selectively localizes to the retina and pineal gland, has been identified as the target for the putative pathogenic autoimmune process of cancer-associated retinopathy (CAR). The present study was aimed at testing the capacity of recoverin to induce experimental autoimmune uveoretinitis and pinealitis in Lewis rats. METHODS Lewis rats were imm...
متن کاملRPE65 is highly uveitogenic in rats.
PURPOSE To examine the hypothesis that RPE65, a protein specific to the retinal pigment epithelium, is uveitogenic in rats. METHODS Rats of four inbred strains (Lewis, Brown Norway, Fischer, and SHR) were immunized with native or recombinant bovine RPE65, or with S-antigen (S-Ag), emulsified with complete Freund adjuvant, and treated simultaneously with killed Bordetella pertussis bacteria, a...
متن کاملThe Cellular Reaction to Intraperitoneally Injected Blood *
The well-known variation in the reactions to hemorrhage in the tissues is the basis of the study presented in this report, dealing primarily with the changes that occur in the extravasated red blood cells and particularly with the monocytic response. The problems of the fat and iron partides found both in the monocytes and elsewhere in the vicinity of hemorrhage are considered in detail, and th...
متن کاملExperimental autoimmune anterior uveitis. The preparation of uveitogenic ocular melanin.
PURPOSE The purpose of this study was to develop a rapid procedure for the preparation of melanin with a specific, highly uveitogenic activity. METHODS A crude melanosome fraction was isolated from bovine choroids (containing remnants of adhering retinal pigment epithelium). The fraction was extracted with hot 2% sodium dodecyl sulfate, and Lewis rats were immunized with the purified melanin,...
متن کاملDisposition of Intraperitoneally Injected Calcium-45 in Suckling Rats
The time course of the concentration of radiocalcium was studied in the serum, skeleton, pelt, muscles, and pooled internal organs of 10-day-old rats. Within 10 hours of injection, the specific activity of the tissue groups exceeded the specific activity of the serum and remained above it during the period studied (120 hours). Chemical and autoradiographic analyses showed how rapidly most of th...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 1996
ISSN: 0014-4835
DOI: 10.1006/exer.1996.0024